Grapevine extract

dionysosWine has been produced for thousands of years, with evidence of ancient wine production in Georgia from c. 6000 BC (the earliest known traces of wine), West Azerbaijan province of Iran from c. 5000 BC, Armenia from c. 4100 BC (large-scale production), and Sicily from c. 4000 BC. The earliest evidence of a grape and rice mixed based fermented drink sometimes compared to wine was found in ancient China (c. 7000 BC).

The altered consciousness produced by wine has been considered religious since its origin. Moses as he led the exodus of Jews from Egypt sent messengers throughout the promised land in search for fruit and food. The grapevine was one of the fruit brought back by the messengers. The vine is regarded as the symbol of the children of Abraham. (Numbers 13: 20-23). The ancient Greeks worshiped Dionysus or Bacchus and the Ancient Romans carried on his cult. Consumption of ritual wine, probably a certain type of sweet wine originally, was part of Jewish practice since Biblical times and, as part of the eucharist commemorating Jesus's Last Supper, became even more essential to the Christian Church. Although Islam nominally forbade the production or consumption of wine, during its Golden Age, alchemists such as Geber pioneered wine's distillation for medicinal and industrial purposes such as the production of perfume.

Wine production and consumption increased, burgeoning from the 15th century onwards as part of European expansion. Despite the devastating 1887 phylloxera louse infestation, modern science and technology adapted and industrial wine production and wine consumption now occur throughout the world.

While wine and grapes are the most known and valuable grapevine products, several waste products derive from this industry, such as must, grape water and leaves, the last being one of the most abundant waste products in the wine industry. This sub-product is considered a delicacy in many countries, including in the Mediterranean Basin. In fact, Mediterranean countries such as Turkey, Greece and Bulgaria cultivate specific grapevine cultivars especially for fresh and preserved leaf consumption.

The Mediterranean-type diet has been demonstrated to have numerous health benefits, namely on cardiometabolic diseases, diabetes and preventing certain types of cancer. Moreover, recently its impact in decreasing the risk of mental disorders, including depression, has also been highlighted. A wider inclusion of this disregarded by-product in the human diet or its use as a source of bioactive compounds is a good strategy, not only to introduce an added value to a waste product but also to come upon the European Union and United Nations’ demands towards more sustainable agricultural approaches and circular economy (Goals of the 2030 Agenda for Sustainable Development).

The increasing search for healthier diets as well as new products with health promoting characteristics, has drawn attention to grapevine leaves in the last few years. Grapevine leaves have already shown to be an excellent source of bioactive molecules, mainly phenolic compounds, and their antioxidant properties have been described to protect from and retard oxidative processes.

Leaves from Vitis vinifera L. represent the less studied and valorized wastes of grape crops and the winery industry. This study aims thus to perform for the first time a deepened assessment of the bioactive compounds in grapevine leaves. The detailed composition of main phytochemicals involved in the high antioxidant of grape leaves (2.20 g TE/100 g) was determined including:

  • carotenoids (lutein, β-carotene)
  • tocopherols (α and ɣ-tocopherol)
  • polyphenols (phenolics acids, flavonoids)
  • phytosterols (β-sitosterol)


In particular, high levels of lutein (0.3–1.0 g/kg) and α-tocopherol (0.2–1.2 g/kg) were observed. Moreover, the evolution of bioactive compounds during 7 harvesting times from July to October was also studied showing that the content of phytochemicals fluctuates according to the development stage of grape leaves. Phytosterols for example reached their highest levels in leaves in the later stage of maturation (T6 – T7) with values around 169 ± 40 mg/kg.

The studies have shown that grape leaves are the best source of resveratrol–they are up to one hundred times richer in resveratrol than the fruits. It is believed that plants produce resveratrol to help ward off fungus. The leaves are also rich source of quercitineas the whole plant.




Grape-Vine Leaf Extract (Vitis vinifera) is a rich source of numerous polyphenols from which resveratrol is the most important. Plants containing resveratrol have been used effectively in traditional medicine for over 2000 years. It can be found in some plants, fruits, and derivatives, such as red wine. Therefore, it can be administered by either consuming these natural products or intaking nutraceutical pills. Resveratrol exhibits a wide range of beneficial properties, and this may be due to its molecular structure, which endow resveratrol with the ability to bind to many biomolecules. Among these properties its activity as an anticancer agent, a platelet antiaggregation agent, and an antioxidant, as well as its antiaging, antifrailty, anti-inflammatory, antiallergenic, and so forth activities, is worth highlighting. These beneficial biological properties have been extensively studied in humans and animal models, both in vitro and in vivo. The issue of bioavailability of resveratrol is of paramount importance and is determined by its rapid elimination and the fact that its absorption is highly effective, but the first hepatic step leaves little free resveratrol. Clarifying aspects like stability and pharmacokinetics of resveratrol metabolites would be fundamental to understand and apply the therapeutic properties of resveratrol.

Resveratrol also has positive impact on the circulatory system (improves oxygenation of the body) and the immune system (improves immunity) and supports the detoxification of the body.


Quercetin is a plant pigment from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, seeds, and grains; capers, red onions, and kale are common foods containing appreciable amounts of it. It has a bitter flavor and is used as an ingredient in dietary supplements, beverages, and foods.

Flavonoids, such as quercetin, are antioxidants. They scavenge particles in the body known as free radicals which damage cell membranes, tamper with DNA, and even cause cell death. Antioxidants can neutralize free radicals. They may reduce or even help prevent some of the damage free radicals cause. In test tubes, quercetin has strong antioxidant properties. But researchers are not sure whether taking quercetin (and many other antioxidants) has the same effects inside the body.

Hereinafter are listed some health conditions where quercetin consumption may have positive effect.

  • Allergies, asthma, hay fever and hives
  • Heart disease
  • High cholesterol
  • Hypertension
  • Interstitial cystitis
  • Prostatitis
  • Rheumatoid arthritis (RA)
  • Cancer
  • Cataract
  • AIDS
  • Diabetes

In addition, quercetin has a protective effect on vitamins C and E, preventing the oxidation of ascorbate, through the possibility of chelation of copper ions and other transition metals. It strengthens blood vessels, thanks to which it supports the treatment of subcutaneous bleeding, hemorrhoids, varicose veins, as well as reduces blood clots, hence it also has anti-atherosclerotic properties.

Red Grape Leaf Extract (Red vine leaf extract = RVLE) brings relief to tired and swollen legs. It has a soothing, anti-swelling and relaxing effect. Red grape leaves contain active substances that have the ability to strengthen connective tissue. The red grape leaves contain ingredients that help to remove swelling of the feet and limbs and relieve pain, significantly supporting regenerative processes. The effect of red grape leaves has been confirmed in clinical trials. Preparations containing red grape leaf extract strengthen blood vessels and prevent them from breaking, improve circulation and effectively reduce leg pain caused by varicose veins.

If you are looking for more information
about symptoms, diagnosis,
causes and treatment!

About fibromyalgia
proMyalgan cream

Are you interested in
composition and mode of action?

Find out more!
Myalgan ↔ proMyalgan

Want to know
how they differ?

Check that!

If you would like to contact us:

Phytomedica Poland
   22 Farbiarska street, PL 02-862 Warsaw, Poland
  +48 22 487 14 44
  +48 22 651 75 40

Contact Form

If you have not found the answer you are looking for, please fill in this contact form and send it to our expert!

I consent to the processing of my personal data by the Administrator, i.e. Phytomedica Polska with its registered office in Konstancin-Jeziorna, ul. Czereśniowa 28, 05-520 Konstancin-Jeziorna for purposes related to the use of the contact form. I provide the data voluntarily, I declare that I am aware that I have the right to access, correct and delete my data.

Enter the code shown in the picture
This is a captcha-picture. It is used to prevent mass-access by robots. (see:

Before submitting the form, make sure that the e-mail address provided is correct!